Publications

Below is a list of some of the group’s recent pre-prints and publications. More can be found on Google Scholar.

Pre-prints

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Anubha Mahajan, Cassandra N Spracklen*, Weihua Zhang*, Maggie CY Ng*, Lauren E Petty*, Hidetoshi Kitajima*, Grace Z Yu*, Sina Rüeger*, Leo Speidel*, …, Simon R Myers, Jorge Ferrer, Kyle J Gaulton, James B Meigs, Karen L Mohlke, Anna L Gloyn, Donald W Bowden, Jennifer E Below, John C Chambers, Xueling Sim, Michael Boehnke, Jerome I Rotter, Mark I McCarthy, Andrew P Morris. medRxiv (2020). DOI: 10.1101/2020.09.22.20198937

Publications

Altering the Binding Properties of PRDM9 Partially Restores Fertility across the Species Boundary

Benjamin Davies, Anjali Gupta Hinch, Alberto Cebrian-Serrano, Samy Alghadban, Philipp W Becker, Daniel Biggs, Polinka Hernandez-Pliego, Chris Preece, Daniela Moralli, Gang Zhang, Simon Myers, Peter Donnelly. Molecular Biology and Evolution (2021). DOI: 10.1093/molbev/msab269

Inferring population histories for ancient genomes using genome-wide genealogies

Leo Speidel, Lara Cassidy, Robert W Davies, Garrett Hellenthal, Pontus Skoglund, Simon R Myers. Molecular Biology and Evolution (2021). DOI: 10.1093/molbev/msab174

Rapid genotype imputation from sequence with reference panels

Robert W Davies, Marek Kucka, Dingwen Su, Sinan Shi, Maeve Flanagan, Christopher M Cunniff, Yingguang Frank Chan, Simon Myers. Nature Genetics (2021). DOI: 10.1038/s41588-021-00877-0

ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair

Daniel Wells, Emmanuelle Bitoun, Daniela Moralli, Gang Zhang, Anjali Hinch, Julia Jankowska, Peter Donnelly, Catherine Green, Simon R Myers. eLife (2020). DOI: 10.7554/eLife.53392

A method for genome-wide genealogy estimation for thousands of samples

Leo Speidel, Marie Forest, Sinan Shi, Simon R Myers. Nature Genetics (2019). DOI: 10.1038/s41588-019-0484-x

A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination

Ran Li, Emmanuelle Bitoun, Nicolas Altemose, Robert W Davies, Benjamin Davies, Simon R Myers. Nature Communications (2019). DOI: 10.1038/s41467-019-11675-y

Fine-scale inference of ancestry segments without prior knowledge of admixing groups

Michael Salter-Townshend, Simon Myers. Genetics (2019). DOI: 10.1534/genetics.119.302139

Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

Min Jung*, Daniel Wells*, Janette Rusch, Suhaira Ahmed, Jonathan Marchini, Simon R Myers, Donald Conrad. eLife (2019). DOI: 10.7554/eLife.43966

Patterns of genetic differentiation and the footprints of historical migrations in the Iberian Peninsula

Clare Bycroft, Ceres Fernandez-Rozadilla, Clara Ruiz-Ponte, Inés Quintela, Ángel Carracedo, Peter Donnelly, Simon Myers. Nature Communications (2019). DOI: 10.1038/s41467-018-08272-w

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

Nicolas Altemose, Nudrat Noor, Emmanuelle Bitoun, Afidalina Tumian, Michael Imbeault, J Ross Chapman, A Radu Aricescu, Simon R Myers. eLife (2017). DOI: 10.7554/eLife.28383

Rapid genotype imputation from sequence without reference panels

Robert W Davies, Jonathan Flint, Simon Myers, Richard Mott. Nature Genetics (2016). DOI: 10.1038/ng.3594

Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice

Benjamin Davies, Edouard Hatton, Nicolas Altemose, Julie G Hussin, Florencia Pratto, Gang Zhang, Anjali Gupta Hinch, Daniela Moralli, Daniel Biggs, Rebeca Diaz, Chris Preece, Ran Li, Emmanuelle Bitoun, Kevin Brick, Catherine M Green, R Daniel Camerini-Otero, Simon R Myers, Peter Donnelly. Nature (2016). DOI: 10.1038/nature16931

Evidence for a common origin of blacksmiths and cultivators in the Ethiopian Ari within the last 4500 years: lessons for clustering-based inference

Lucy van Dorp, David Balding, Simon Myers, Luca Pagani, Chris Tyler-Smith, Endashaw Bekele, Ayele Tarekegn, Mark G Thomas, Neil Bradman, Garrett Hellenthal. PLOS Genetics (2015). DOI: 10.1371/journal.pgen.1005397