Publications
Below is a list of some of the group’s recent preprints and publications. More can be found on Google Scholar.
Preprints
Leveraging fine-scale population structure reveals conservation in genetic effect sizes between human populations across a range of human phenotypes
Sile Hu, Lino A. F. Ferreira, Sinan Shi, Garrett Hellenthal,† Jonathan Marchini,† Daniel J. Lawson,† Simon R. Myers.† bioRxiv (2023). DOI: 10.1101/2023.08.08.552281
The distribution of branch duration and detection of inversions in ancestral recombination graphs
Anastasia Ignatieva, Martina Favero, Jere Koskela, Jaromir Sant, Simon R. Myers. bioRxiv (2023). DOI: 10.1101/2023.07.11.548567
Publications
A Genomics England haplotype reference panel and imputation of UK Biobank
Sinan Shi, Simone Rubinacci, Sile Hu, Loukas Moutsianas, Alex Stuckey, Anna C Need, Pier Francesco Palamara, Mark Caulfield, Jonathan Marchini, Simon Myers. Nature Genetics (2024). DOI: 10.1038/s41588-024-01868-7
Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs
Ipsita Agarwal*, Zachary L. Fuller*, Simon R. Myers, Molly Przeworski. eLife (2023). DOI: 10.7554/eLife.83172
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Anubha Mahajan, Cassandra N. Spracklen, Weihua Zhang, Maggie C. Y. Ng, Lauren E. Petty, Hidetoshi Kitajima, Grace Z. Yu, Sina Rüeger, Leo Speidel, …, Simon R. Myers, …, Anna L. Gloyn,† Donald W. Bowden,† Jennifer E. Below,† John C. Chambers,† Xueling Sim,† Michael Boehnke,† Jerome I. Rotter,† Mark I. McCarthy,† Andrew P. Morris.† Nature Genetics (2022). DOI: 10.1038/s41588-022-01058-3
Altering the Binding Properties of PRDM9 Partially Restores Fertility across the Species Boundary
Benjamin Davies, Anjali Gupta Hinch, Alberto Cebrian-Serrano, Samy Alghadban, Philipp W. Becker, Daniel Biggs, Polinka Hernandez-Pliego, Chris Preece, Daniela Moralli, Gang Zhang, Simon Myers, Peter Donnelly. Molecular Biology and Evolution (2021). DOI: 10.1093/molbev/msab269
Inferring population histories for ancient genomes using genome-wide genealogies
Leo Speidel, Lara Cassidy, Robert W. Davies, Garrett Hellenthal, Pontus Skoglund, Simon R. Myers. Molecular Biology and Evolution (2021). DOI: 10.1093/molbev/msab174
Rapid genotype imputation from sequence with reference panels
Robert W. Davies, Marek Kucka, Dingwen Su, Sinan Shi, Maeve Flanagan, Christopher M. Cunniff, Yingguang Frank Chan, Simon Myers. Nature Genetics (2021). DOI: 10.1038/s41588-021-00877-0
ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair
Daniel Wells, Emmanuelle Bitoun, Daniela Moralli, Gang Zhang, Anjali Hinch, Julia Jankowska, Peter Donnelly, Catherine Green, Simon R. Myers. eLife (2020). DOI: 10.7554/eLife.53392
A method for genome-wide genealogy estimation for thousands of samples
Leo Speidel, Marie Forest, Sinan Shi, Simon R. Myers. Nature Genetics (2019). DOI: 10.1038/s41588-019-0484-x
A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination
Ran Li, Emmanuelle Bitoun, Nicolas Altemose, Robert W. Davies, Benjamin Davies, Simon R. Myers. Nature Communications (2019). DOI: 10.1038/s41467-019-11675-y
Fine-scale inference of ancestry segments without prior knowledge of admixing groups
Michael Salter-Townshend, Simon Myers. Genetics (2019). DOI: 10.1534/genetics.119.302139
Unified single-cell analysis of testis gene regulation and pathology in five mouse strains
Min Jung*, Daniel Wells*, Janette Rusch, Suhaira Ahmed, Jonathan Marchini, Simon R. Myers, Donald Conrad. eLife (2019). DOI: 10.7554/eLife.43966
Patterns of genetic differentiation and the footprints of historical migrations in the Iberian Peninsula
Clare Bycroft, Ceres Fernandez-Rozadilla, Clara Ruiz-Ponte, Inés Quintela, Ángel Carracedo, Peter Donnelly,† Simon Myers.† Nature Communications (2019). DOI: 10.1038/s41467-018-08272-w
A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
Nicolas Altemose, Nudrat Noor, Emmanuelle Bitoun, Afidalina Tumian, Michael Imbeault, J. Ross Chapman, A. Radu Aricescu, Simon R. Myers. eLife (2017). DOI: 10.7554/eLife.28383
Rapid genotype imputation from sequence without reference panels
Robert W. Davies, Jonathan Flint, Simon Myers†, Richard Mott.† Nature Genetics (2016). DOI: 10.1038/ng.3594
Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice
Benjamin Davies, Edouard Hatton, Nicolas Altemose, Julie G. Hussin, Florencia Pratto, Gang Zhang, Anjali Gupta Hinch, Daniela Moralli, Daniel Biggs, Rebeca Diaz, Chris Preece, Ran Li, Emmanuelle Bitoun, Kevin Brick, Catherine M. Green, R. Daniel Camerini-Otero, Simon R. Myers,† Peter Donnelly.† Nature (2016). DOI: 10.1038/nature16931
Evidence for a common origin of blacksmiths and cultivators in the Ethiopian Ari within the last 4500 years: lessons for clustering-based inference
Lucy van Dorp, David Balding, Simon Myers, Luca Pagani, Chris Tyler-Smith, Endashaw Bekele, Ayele Tarekegn, Mark G. Thomas, Neil Bradman, Garrett Hellenthal. PLOS Genetics (2015). DOI: 10.1371/journal.pgen.1005397